Generic Dzina:venetoclax (ven ET oh klax)
Dzina la Brand: Venclexta, Venclexta Starting Pack

Venetoclax amagwiritsidwa ntchito pochiza matenda a lymphocytic leukemia kapena ang'onoang'ono a lymphocytic leukemia mwa akuluakulu.Venetoclax imagwiritsidwa ntchito yokha kapena kuphatikiza ndi mankhwala ena a khansa pochiza izi.

Venetoclax amagwiritsidwa ntchito limodzi ndi azacitidine, decitabine, kapena cytarabine pofuna kuchiza myeloid leukemia.Kusakaniza kumeneku kumagwiritsidwa ntchito kwa akuluakulu omwe ali ndi zaka 75 kapena kuposerapo, kapena omwe sangathe kugwiritsa ntchito mankhwala amphamvu a chemotherapy chifukwa cha matenda ena.

Venetoclax nthawi zina amaperekedwa pambuyo poti mankhwala ena alephera.

Venetoclax itha kugwiritsidwanso ntchito pazinthu zomwe sizinalembedwe mu bukhuli lamankhwala.

Kufotokozera

Venetoclax (ABT-199; GDC-0199) ndi yamphamvu kwambiri, yosankha komanso yopezeka pakamwa ya Bcl-2 inhibitor yokhala ndi Ki yosakwana 0.01 nM.Venetoclax imayambitsa autophagy.

Mu Vitro

Venetoclax (ABT-199) imapha mwamphamvu maselo a FL5.12-BCL-2 (EC50 = 4 nM), Venetoclax (ABT-199) imasonyeza ntchito yofooka kwambiri motsutsana ndi maselo a FL5.12-BCL-XL (EC50 = 261 nM).ABT-199 imawonetsanso kusankhidwa kwa ma cell a mammalian two-hybrid assays, pomwe imasokoneza BCL-2-BIM complexes (EC50=3 nM) koma imakhala yocheperako polimbana ndi BCL-XL-BCL-XS (EC50=2.2)μM) kapena MCL-1-NOXA zovuta.

Pambuyo pa mlingo umodzi wapakamwa wa 12.5 mg pa kilogalamu ya kulemera kwa thupi mu xenografts yochokera ku RS4; maselo a 11 (ALL), Venetoclax (ABT-199) imayambitsa chotupa chachikulu choletsa kukula (TGImax) cha 47% (P <0.001) ndi kukula kwa chotupa kuchedwa (TGD) kwa 26% (P<0.05)[1].

Chithandizo cha zotupa za xenografted (mouse xenograft model wa T-ALL cell line LOUCY) zotupa ndi Venetoclax (ABT-199) 100 mg/kg kwa masiku 4 zimabweretsa kuchepa kwakukulu kwa leukemic katundu.