Bictegravir 1611493-60-7
Kufotokozera
Bictegravir ndi novel, inhibitor yamphamvu ya HIV-1 integrase yokhala ndi IC50 ya 7.5 nM.
Mu Vitro
Bictegravir (BIC) imalepheretsa kusintha kwa chingwe ndi IC50 ya 7.5± 0.3 nm.Mogwirizana ndi kuletsa kwake kusuntha kwa strand, Bictegravir ndi inhibitor yofooka kwambiri ya 3.''-kukonza ntchito ya HIV-1 IN, yokhala ndi IC50 ya 241±51 nm.Bictegravir imapangitsa kudzikundikira kwa 2-LTR mabwalo ~ 5-fold pokhudzana ndi kuwongolera konyozedwa ndikuchepetsa kuchuluka kwa zophatikizika zenizeni m'maselo omwe ali ndi kachilombo ndi 100-fold.Bictegravir imalepheretsa kubwereza kwa HIV-1 m'maselo onse a MT-2 ndi MT-4 okhala ndi ma EC50 a 1.5 ndi 2.4 nM, motsatana.Bictegravir imasonyeza mphamvu zowononga tizilombo toyambitsa matenda m'ma CD4+ T lymphocytes ndi macrophages opangidwa ndi monocyte, ndi EC50s ya 1.5±0.3 nM ndi 6.6±4.1 nM, motsatira, zomwe zimafanana ndi zomwe zimapezeka mu T-cell mizere[1].
MCE sinatsimikizire paokha kulondola kwa njirazi.Iwo ndi ongowafotokozera okha.
| Nambala ya NCT | Wothandizira | Mkhalidwe | Tsiku loyambira | Gawo |
| NCT03998176 | Yunivesite ya Nebraska | Gileadi Sayansi | HIV-1 - matenda | October 9, 2019 | Gawo 4 |
| NCT03789968 | Thomas Jefferson University|University of Maryland, College Park|Indiana University Health|The Brooklyn Hospital Center|University of Illinois ku Chicago|Nova Southeastern University|University of California, San Francisco | HIV + Edzi | Seputembara 1, 2019 | |
| NCT04249037 | Yunivesite ya Colorado, Denver | Gileadi Sayansi | HIV + Edzi | Marichi 1, 2020 | Zosafunika |
| NCT04132674 | Vancouver Infectious Diseases Center | Human Immunodeficiency Virus I Infection| Kugwiritsa Ntchito Mankhwala Osokoneza Bongo | Novembala 26, 2018 | Gawo 4 |
| NCT04054089 | Cristina Mussini|University of Modena ndi Reggio Emilia | Matenda a HIV | Seputembara 2019 | Gawo 4 |
| NCT04155554 | Azienda Ospedaliera Universitaria Senese|Catholic University of the Sacred Heart|Ospedale Policlinico San Martino|Azienda Ospedaliera San Paolo|Ospedale Amedeo di Savoia | HIV-1 - matenda | Januware 29, 2020 | Gawo 3 |
| NCT02275065 | Sayansi ya Gileadi | Kachilombo ka HIV-1 | October 2014 | Gawo 1 |
| NCT03711253 | Yunivesite ya Southern California | Kachilombo ka HIV | October 14, 2019 | Gawo 4 |
| NCT02400307 | Sayansi ya Gileadi | HIV | Epulo 17, 2015 | Gawo 1 |
| NCT03499483 | Fenway Community Health | Kupewa HIV | Januware 24, 2019 | Gawo 4 |
| NCT03502005 | Midland Research Group, Inc.|Gileadi Sciences | Human Immunodeficiency Virus | Marichi 1, 2018 | Gawo 4 |
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