Sacubitril Hemicalcium

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Sacubitril Hemicalcium   M'nyumba      


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PRODUCT DETAIL

沙库比曲半钙盐 Sacubitril Hemicalcium 1369773-39-6 M'nyumba
沙库比曲钠盐 149690-05-1 M'nyumba
Chithunzi cha LCZ-4 1426129-50-1 M'nyumba
Chithunzi cha LCZ-7 1012341-48-8 M'nyumba
Chithunzi cha LCZ-8 1012341-50-2 M'nyumba
Chithunzi cha LCZ-9 149690-12-0 M'nyumba

 

Mbiri

AHU-377 hemicalcium mchere ndi mtundu wa mchere wa hemicalcium wa AHU-377.Ndi inhibitor ya neprilysin yokhala ndi IC50 mtengo wa 5 nM [1].

AHU-377 ndi angiotensin II AT1 receptor antagonist valsartan amapanga LCZ696 mu 1: 1 molar ratio.LCZ696 ndi angiotensin receptor neprilysin inhibitor.Ikhoza kuchepetsa kuthamanga kwa magazi ndipo ikhoza kukhala mankhwala atsopano ochizira matenda a mtima.AHU-377 ndi pro-mankhwala, imatha kusinthidwa ndi enzymatic cleavage ya ethyl ester mu mawonekedwe yogwira LBQ657.Zimanenedwa kuti AHU-377 (30 ndi 100 mg / kg, PO) ikhoza kuyambitsa zotsatira za antihypertensive m'njira yodalira mlingo mu makoswe a DAHI-SS.Koma mu makoswe a DOCA-mchere wambiri, amasonyeza kuchepa kofooka [2, 3].

Zolozera:
[1] Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A. Dicarboxylic acid dipeptide neutral endopeptidase inhibitors.J Med Chem.1995 May 12;38(10):1689-700.
[2] Voors AA, Dorhout B, van der Meer P. Ntchito yotheka ya valsartan + AHU377 (LCZ696) pochiza matenda a mtima.Katswiri Opin Investig Mankhwala Osokoneza Bongo.2013 Aug;22(8):1041-7.
[3] Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi et al.Kuyerekeza kwamphamvu kwa AHU-377, mphamvu ya neprilysin inhibitor, mumitundu iwiri ya makoswe a kuthamanga kwa magazi kodalira voliyumu.BMC Pharmacology 2011, 11(Suppl 1):P33.

Kapangidwe ka mankhwala

Sacubitril Hemicalcium

CERTIFICATE

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

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Quality management1

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