Mbiri

AHU-377 hemicalcium mchere ndi mtundu wa mchere wa hemicalcium wa AHU-377. Ndi inhibitor ya neprilysin yokhala ndi IC50 mtengo wa 5 nM [1].

AHU-377 ndi angiotensin II AT1 receptor antagonist valsartan amapanga LCZ696 mu 1: 1 molar ratio. LCZ696 ndi angiotensin receptor neprilysin inhibitor. Ikhoza kuchepetsa kuthamanga kwa magazi ndipo ikhoza kukhala mankhwala atsopano ochizira matenda a mtima. AHU-377 ndi pro-mankhwala, imatha kusinthidwa ndi enzymatic cleavage ya ethyl ester kukhala yogwira mawonekedwe LBQ657. Zimanenedwa kuti AHU-377 (30 ndi 100 mg / kg, PO) ikhoza kuyambitsa zotsatira za antihypertensive m'njira yodalira mlingo mu makoswe a DAHI-SS. Koma mu makoswe a DOCA-mchere wambiri, amasonyeza kuchepa kofooka [2, 3].

Zolozera:
[1] Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A. Dicarboxylic acid dipeptide neutral endopeptidase inhibitors. J Med Chem. 1995 May 12; 38(10):1689-700.
[2] Voors AA, Dorhout B, van der Meer P. Ntchito yotheka ya valsartan + AHU377 (LCZ696) pochiza matenda a mtima. Katswiri Opin Investig Mankhwala Osokoneza Bongo. 2013 Aug;22(8):1041-7.
[3] Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi et al. Kuyerekeza kwamphamvu kwa AHU-377, mphamvu ya neprilysin inhibitor, mumitundu iwiri ya makoswe a kuthamanga kwa magazi kodalira voliyumu. BMC Pharmacology 2011, 11(Suppl 1):P33.

Kapangidwe ka mankhwala