Kufotokozera

Sugammadex sodium ndi yopangidwa ndi γ-cyclodextrin, ndipo imakhala ngati chosinthira chatsopano cha neuromuscular block.

Dzina Lodziwika: sugammadex (soo GAM ma dex)
Dzina la Brand: Bridion

Sugammadex imasintha zotsatira za mankhwala ena omwe amaperekedwa panthawi ya opaleshoni kuti athetse minofu yanu.

Sugammadex imagwiritsidwa ntchito kumapeto kwa opaleshoni, kuthandiza kubwezeretsa ntchito ya minofu yomwe yatsekedwa panthawi ya opaleshoni ndi mankhwala ena.

Sugammadex itha kugwiritsidwanso ntchito pazinthu zomwe sizinalembedwe mu bukhuli lamankhwala.

Amagwiritsidwa ntchito kuti asinthe zotsatira za mankhwala ena.

Mu Vivo

Jekeseni wa sugammadex alibe zotsatira zazikulu pa kuthamanga kwa magazi kapena kugunda kwa mtima. Pambuyo pa jekeseni wa mlingo waukulu wa rocuronium, kuchira kwa 90% kwa chiŵerengero cha sitima ya anayi kumatenga 28 min (SD 7 min) pambuyo pa saline, 26 min (SD 9.5 min) pambuyo pa 1 mg / kg sugammadex, ndi 8 min (SD) 3.6 min) pambuyo pa 2.5 mg/kg sugammadex[1]. Sugammadex imayambitsa kusinthika mwachangu komanso kwathunthu kwa rocuronium-induced neuromuscular block. Nthawi yobwezeretsa yophunzitsira anayi = 0.9 pambuyo pochira mwadzidzidzi ndi 14.4 min (SD = 3.4 min; n = 14). Izi zimachepetsedwa kwambiri ku 3.7 min (SD = 3.3 min; n = 4) ndi sugammadex 0.5 mg / kg ndi 1.9 min (SD = 1.0 min; n = 4) ndi sugammadex 1.0 mg / kg [2]. Theka la moyo wa sugammadex mu Rhesus nyani ndi 30 (SEM = 4.9) min[3].

Kusungirako

Kapangidwe ka mankhwala