Relugolix amagwiritsidwa ntchito pochiza khansa ya prostate mwa amuna.
Dzina la Brand: Orgovyx
Kalasi ya Mankhwala: Antineoplastic - LHRH (GnRH) Antagonist Pituitary Suppressants
Kupezeka: Zolemba Zofunika
Mimba: Funsani dokotala wanu. Mankhwalawa akhoza kukhala ovulaza kwa mwana wosabadwa.
Kuyamwitsa: Funsani dokotala musanagwiritse ntchito

Relugolix ndi mdani wopezeka pakamwa, wopanda peptide gonadotropin-release hormone (GnRH kapena luteinizing hormone-releasing hormone (LHRH))), wokhala ndi zochita za antiineoplastic. Relugolix mopikisana amamanga ndi kutsekereza cholandilira cha GnRH mu anterior pituitary gland, zomwe zonse zimalepheretsa GnRH kumangirira ku GnRH receptor ndikuletsa kutulutsa ndi kutulutsa kwa onse a luteinizing hormone (LH) ndi follicle stimulating hormone (FSH). Mwa amuna, kuletsa kwa LH secretion kumalepheretsa kutulutsidwa kwa testosterone kuchokera ku maselo a Leydig m'ma testes. Popeza testosterone imafunika kuti prostate ikule, kuchepetsa milingo ya testosterone kungalepheretse kuchuluka kwa maselo a khansa ya prostate yodalira mahomoni.

Relugolix ndi gonadotropin-release hormone (GnRH) receptor antagonist yomwe imagwiritsidwa ntchito pochiza matenda angapo omwe amakhudzidwa ndi mahomoni. Idavomerezedwa koyamba ku Japan mu 2019, pansi pa dzina la Relumina, pochiza matenda a uterine fibroids, ndipo posachedwa ndi United States' FDA mu 2020, pansi pa dzina la Orgovyx, pochiza khansa ya prostate. Relugolix adaphunziranso mu chithandizo cha symptomatic cha endometriosis. Relugolix ndiye woyamba (ndipo pano yekha) yemwe amalandila pakamwa GnRH receptor antagonist wovomerezeka kuti azichiza khansa ya prostate - machiritso ofanana ndi [degarelix] amafunikira subcutaneous management - motero amapereka njira yochizira yosalemetsa kwa odwala omwe angafunike kupita kuchipatala. zoyendetsedwa ndi akatswiri azaumoyo. Kuphatikiza pa kugwiritsa ntchito kwake kosavuta, relugolix idawonetsedwa kukhala yopambana pakupsinjika kwa milingo ya testosterone poyerekeza ndi [leuprolide], mankhwala ena oletsa androgen omwe amagwiritsidwa ntchito pochiza khansa ya prostate.

Relugolix ndi Gonadotropin Releasing Hormone Receptor Antagonist. Limagwirira ntchito ya relugolix ndi monga Gonadotropin Kutulutsa Hormone Receptor Antagonist, ndi Cytochrome P450 3A Inducer, ndi Cytochrome P450 2B6 Inducer, ndi Breast Cancer Resistance Protein Inhibitor, ndi P-Glycoprotein Inhibitor. Mphamvu ya physiologic ya relugolix imachokera ku Kuchepetsa kwa GnRH Secretion.

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