Daclatasvir Dihydrochloride
Kufotokozera
Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) ndi yamphamvu komanso yogwira pakamwa.HCV NS5A mapuloteniinhibitor ndiEC50s osiyanasiyana 9-146 pM kwaangapo HCV replicon genotypes.Daclatasvir dihydrochloride ndiyenso aorganic anion transporting polypeptide 1B (OATP1B)ndiChithunzi cha OATP1B3inhibitor ndiIC50s a 1.5 µM ndi 3.27 µM, motsatana.
IC50& Cholinga
EC50: 50 pM (HCV replicon genotype 1a), 9 pM (HCV replicon genotype 1b), 71 pM (HCV replicon genotype 2a), 146 pM (HCV replicon genotype 3a), 12 pM (HCV replicon genotype 34a) HCV replicon genotype 5a)[1]
Kd: 8 nM (NS5A33-202) ndi 210 nM (NS5A26-202)[2]
IC50: 1.5 µM (OATP1B) ndi 3.27 µM (OATP1B3)[3]
Mu Vitro
Daclatasvir (BMS-790052) ikuwonetsa ntchito zoletsa zoletsa ma genotypes onse oyesedwa, ndi EC50mitengo kuyambira 9pm mpaka 146pm.Daclatasvir imaletsa HCV replicon genotype 1a, 1b, 2a, 3a, 4a ndi 5a ndi EC5050 pM, 9 pM, 71 pM, 146 pM, 12 pM ndi 33 pM motsatira.Daclatasvir ndi choletsa champhamvu cha JFH-1 genotype 2a kachilombo koyambitsa matenda komwe kamatengera chikhalidwe cha cell (EC).50= 28pm)[1].Daclatasvir (BMS-790052) imamanga mwamphamvu ku NS5A33-202 ndi NS5A26-202 ndi Kds ya 8 nM ndi 210 nM, motsatana[2].
Kusungirako
| Ufa | -20 ° C | 3 zaka |
| 4°C | zaka 2 | |
| Mu zosungunulira | -80 ° C | 6 miyezi |
| -20 ° C | 1 mwezi |
Kuyesa Kwachipatala
| Nambala ya NCT | Wothandizira | Mkhalidwe | Tsiku loyambira | Gawo |
| NCT03369327 | Tehran University of Medical Sciences|RojanPharma Pharmaceutical Company | Matenda a Hepatitis C Virus, Response to Therapy of|Human Immunodeficiency Virus | Januware 1, 2017 | Gawo 3 |
| NCT03485846 | R-Pharm|Almedis | Matenda a Chiwindi C Genotype 1b | Novembala 27, 2017 | Gawo 2 |
| NCT01016912 | Bristol-Myers Squibb | Matenda a Hepatitis C | Disembala 2009 | Gawo 2 |
| NCT01629732 | Bristol-Myers Squibb | Hepatitis C Virus | March 2013 | Gawo 2 |
| NCT01497834 | Bristol-Myers Squibb | Chiwindi C | Januware 2012 | Gawo 3 |
| NCT01973049 | Bristol-Myers Squibb | Chiwindi C | December 2013 | Gawo 3 |
| NCT00663208 | Bristol-Myers Squibb | Matenda a Chiwindi C | Meyi 2008 | Gawo 2 |
| NCT02576314 | Humanity and Health Research Center|Beijing 302 Hospital | Matenda a Hepatitis C osatha | May 2015 | Gawo 3 |
| NCT02756936 | Genuine Research Center, Egypt|Zeta Pharma Pharmaceutical Industries | Wathanzi | February 2016 | Gawo 1 |
| NCT02771405 | National Hepatology & Tropical Medicine Research Institute|Cairo University | Hepatitis C, Matenda | Hepatocellular Carcinoma | Marichi 2016 | Gawo 3 |
| NCT03706898 | Viriom | HIV-1-infection|Kuwonongeka kwa chiwindi | October 1, 2018 | Gawo 1 |
| NCT02319031 | Bristol-Myers Squibb | Chiwindi C | February 2015 | Gawo 3 |
| NCT02124044 | National Institutes of Health Clinical Center (CC)|National Institute of Allergy and Infectious Diseases (NIAID)|Bristol-Myers Squibb | HIV-HCV | February 2014 | Gawo 2 |
| NCT02551861 | Bristol-Myers Squibb | Chiwindi C | December 2015 | Gawo 2 |
| NCT00859053 | Bristol-Myers Squibb | Kulephera kwa chiwindi | Marichi 2009 | Gawo 1 |
| NCT01257204 | Bristol-Myers Squibb | Hepatitis C Virus | December 2010 | Gawo 2 |
| NCT03063879 | Tehran University of Medical Sciences|Ahvaz Jundishapur University of Medical Sciences|Shiraz University of Medical Sciences|Hamadan University of Medical Science | Chiwindi C, Chosatha | Kulephera kwa aimpso kwanthawi yayitali | Epulo 1, 2017 | Gawo 4 |
| NCT01017575 | Bristol-Myers Squibb | Matenda a Hepatitis C | Disembala 2009 | Gawo 2 |
| NCT02865369 | Sang Gyune Kim|Seoul National University Boramae Hospital|Severance Hospital|Inha University Hospital|Korea University|Gachon University Gil Medical Center|Hanyang University Seoul Hospital|Ewha Womans University Mokdong Hospital|Bristol-Myers Squibb|Soonchunhyang University Hospital | Matenda a Chiwindi C | Seputembara 2016 |
|
| NCT04070235 | Malingaliro a kampani Nanjing Sanhome Pharmaceutical Co., Ltd. | Chiwindi C, Chosatha | Marichi 29, 2019 | Gawo 2 | Gawo 3 |
| NCT03487848 | Bristol-Myers Squibb | Hepatitis C | Matenda a Chiwindi | Meyi 18, 2018 | Gawo 2 |
| NCT00904059 | Bristol-Myers Squibb | Chiwindi C | Meyi 2009 | Gawo 1 |
| NCT02107365 | French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)|Bristol-Myers Squibb | Hepatitis C Virus Genotype 4 Infection | Novembala 2013 | Gawo 2 |
| NCT02397395 | Janssen R&D Ireland | Kuwonongeka kwa aimpso | Matenda a aimpso omaliza | May 2015 | Gawo 2 |
| NCT03169348 | Yunivesite ya Assiut | Chiwindi C | Novembala 1, 2017 | Zosafunika |
| NCT02323594 | Bristol-Myers Squibb | Matenda a Hepatitis C | December 2014 | Gawo 1 |
| NCT03537196 | French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS) | Hepatitis C | Kugwiritsa Ntchito Mankhwala | Viral Hepatitis C | Novembala 13, 2018 | Gawo 4 |
| NCT02103569 | Bristol-Myers Squibb | Chiwindi C | Epulo 2014 | Gawo 1 |
| NCT02772744 | Zagazig University | Cairo University | Chiwindi C | Novembala 1, 2017 |
|
| NCT01718158 | Bristol-Myers Squibb | Chiwindi C | Januware 2013 | Gawo 3 |
| NCT02496078 | Bristol-Myers Squibb | Chiwindi C | Ogasiti 2015 | Gawo 3 |
| NCT01425970 | Bristol-Myers Squibb | Chiwindi C | Meyi 2012 | Gawo 2 |
| NCT01471574 | Bristol-Myers Squibb | Chiwindi C, Genotype 1 | December 2011 | Gawo 3 |
| NCT01573351 | Bristol-Myers Squibb | Hepatitis C Virus | Meyi 2012 | Gawo 3 |
| NCT01938625 | Janssen R&D Ireland | Chiwindi C, Chosatha | Disembala 12, 2013 | Gawo 2 |
| NCT01492426 | Bristol-Myers Squibb | Chiwindi C | Januware 2012 | Gawo 3 |
| NCT03480932 | Johns Hopkins Bloomberg School of Public Health|National Institute on Drug Abuse (NIDA)|YR Gaitonde Center for AIDS Research and Education | Chiwindi C, Chosatha | February 2, 2018 | Gawo 2 | Gawo 3 |
| NCT03163849 | Yunivesite ya Assiut | Matenda a Chiwindi C | Seputembara 1, 2019 | Gawo 3 |
| NCT01581203 | Bristol-Myers Squibb | Hepatitis C Virus | Meyi 2012 | Gawo 3 |
| NCT01492504 | Bristol-Myers Squibb | Chiwindi C | February 7, 2012 |
|
| NCT03686722 | Mohamed Raslan|Ain Shams University|Drug Research Center, Cairo, Egypt | Diabetes Mellitus, Type 2 | Hepatitis C | Kugwiritsa Ntchito Mankhwala | Seputembara 9, 2017 | Gawo 1 |
| NCT02262728 | Janssen Research & Development, LLC | Chiwindi C, Chosatha | Seputembara 30, 2014 | Gawo 2 |
| NCT02349048 | Janssen Research & Development, LLC | Hepatitis C Virus | Januware 2015 | Gawo 2 |
| NCT03882307 | Yunivesite ya Assiut | Chiwindi C, Chosatha | Meyi 2020 | Gawo loyamba |
| NCT02758509 | Parc de Salut Mar | Matenda a Chiwindi C | Matenda a Cirrhosis | Januware 1, 2010 |
|
| NCT01795911 | Bristol-Myers Squibb | Chiwindi C | March 2013 | Gawo 2 |
| NCT03549832 | Yunivesite ya Assiut | Sohag University | South Valley University | HCV Coinfection | Januware 1, 2018 | Zosafunika |
| NCT02161939 | Bristol-Myers Squibb | Matenda a Chiwindi C |
| |
| NCT01309932 | Bristol-Myers Squibb | Chiwindi C | March 2011 | Gawo 2 |
| NCT01995266 | Bristol-Myers Squibb | Chiwindi C | February 28, 2014 | Gawo 3 |
| NCT02640157 | AbbVie | Matenda a Chiwindi C|Kachilomboka Kachilomboka Kachilomboka | Genotype 3 Kachilombo ka Chiwindi C | December 2015 | Gawo 3 |
| NCT02032875 | Bristol-Myers Squibb | Chiwindi C | March 2014 | Gawo 3 |
| NCT02624063 | Federal University of São Paulo | Chiwindi C, Chosatha | December 2015 | Gawo 4 |
| NCT00546715 | Bristol-Myers Squibb | Matenda a Chiwindi C | Novembala 2007 | Gawo 1 | Gawo 2 |
| NCT01718145 | Bristol-Myers Squibb | Matenda a Hepatitis C Virus | Novembala 2012 | Gawo 3 |
| NCT01616524 | Bristol-Myers Squibb | Hepatitis C Virus (HCV) | July 2012 | Gawo 3 |
| NCT02032901 | Bristol-Myers Squibb | Chiwindi C | Januware 2014 | Gawo 3 |
| NCT03540212 | Yunivesite ya Ain Shams | Matenda a HCV osatha | Disembala 10, 2017 | Gawo 2 | Gawo 3 |
| NCT02097966 | Bristol-Myers Squibb | Matenda a Chiwindi C |
| |
| NCT02596880 | Tehran University of Medical Sciences | Hepatitis C | Cirrhosis | Seputembara 2015 | Gawo 3 |
| NCT04019717 | Malingaliro a kampani Atea Pharmaceuticals, Inc. | Chiwindi C|Chiwindi Chachiwindi C, Chosatha|Chiwindi Chachiwindi C | Matenda a Hepatitis C | Matenda a HCV | Juni 20, 2019 | Gawo 2 |
| NCT02992457 | Tanta University | Chiwindi C | Januware 2015 | Gawo 4 |
| NCT03547895 | Zagazig University | Decompensated Cirrhosis | Juni 1, 2015 | Zosafunika |
| NCT03004625 | Kaohsiung Medical University Chung-Ho Memorial Hospital|Chang Gung Memorial Hospital|National Taiwan University Hospital|Taipei Veterans General Hospital, Taiwan|China Medical University Hospital|National Cheng-Kung University Hospital | Chiwindi C | Novembala 2016 | Gawo 3 |
| NCT01051414 | Bristol-Myers Squibb | Matenda a Hepatitis C | Epulo 2010 | Gawo 2 |
| NCT02309450 | French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)|Bristol-Myers Squibb | Hepatitis C Virus Genotype 4 Infection | December 2014 | Gawo 2 |
| NCT01628692 | Bristol-Myers Squibb|Janssen Research & Development, LLC | Hepatitis C Virus | July 2012 | Gawo 2 |
| NCT03186313 | Chipatala cha Chiwindi cha Egypt | Wadi El Nil Hospital | Chiwindi C | Seputembara 2016 | Gawo 3 |
| NCT03063723 | Chipatala Chachitatu Chogwirizana, Sun Yat-Sen University | Matenda a Chiwindi C (Chisokonezo) | Januware 1, 2016 |
|
| NCT00983957 | Bristol-Myers Squibb | Matenda a Chiwindi C | October 2009 | Gawo 1 |
| NCT01725542 | French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)|Bristol-Myers Squibb | HCV-HIV Co-Infection | December 2012 | Gawo 2 |
| NCT02282709 | Foundation for Liver Research | Matenda a Chiwindi C | February 2014 | Gawo 3 |
| NCT02032888 | Bristol-Myers Squibb | Chiwindi C | February 2014 | Gawo 3 |
| NCT03247296 | MTI University | Chiwindi C | February 28, 2017 |
|
| NCT01389323 | Bristol-Myers Squibb | Chiwindi C | Seputembara 2011 | Gawo 3 |
| NCT02556086 | Bristol-Myers Squibb | Chiwindi C | December 2015 | Gawo 2 |
| NCT01741545 | Bristol-Myers Squibb | Hepatitis C Virus | Marichi 31, 2013 | Gawo 3 |
| NCT01866930 | Bristol-Myers Squibb | Matenda a Hepatitis C osatha | July 11, 2013 | Gawo 3 |
| NCT02268864 | Malingaliro a kampani Janssen-Cilag International NV | Chiwindi C, Chosatha | Januware 2015 | Gawo 2 |
| NCT01797848 | Bristol-Myers Squibb | Chiwindi C | June 2014 | Gawo 3 |
| NCT03166280 | Eman Sayed Hassan Abd Allah|Assiut University | Chiwindi C | June 2017 |
|
| NCT02159352 | Bristol-Myers Squibb | Chiwindi C | June 2014 | Gawo 1 |
| NCT01125189 | Bristol-Myers Squibb | Hepatitis C Virus | July 2010 | Gawo 2 |
| NCT03748745 | Malingaliro a kampani Nanjing Sanhome Pharmaceutical Co., Ltd. | Kugwiritsa Ntchito Mankhwala | Novembala 19, 2018 | Gawo 1 |
| NCT01012895 | Bristol-Myers Squibb | Matenda a Chiwindi C | Disembala 2009 | Gawo 2 |
| NCT02565888 | Yunivesite ya Radboud | Chiwindi C | HIV | Novembala 2015 | Gawo 1 |
| NCT02555943 | Humanity and Health Research Center|Beijing 302 Hospital|Nanfang Hospital of Southern Medical University | Matenda a Hepatitis C | HBV Coinfection|Kuyambitsanso Chiwindi B | February 2015 | Gawo 2 | Gawo 3 |
| NCT02304159 | Tarek I. Hassanein, MD, FACP, FAG, AGAF|Southern California Research Center | Hepatitis C | Cirrhosis | Januware 2015 | Gawo 4 |
| NCT02580474 | Myeong Jun Song|Bristol-Myers Squibb|Soonchunhyang University Hospital|Dankook University|Chungnam National University Hospital|Konyang University Hospital|Eulji University Hospital|Chipatala cha Saint Vincent's, Korea|Chipatala cha Konkuk University|Chipatala cha Cheongju St. Mary's, Cheongju , Korea|Chipatala cha Severance|Korea University Guro Hospital|Eulji General Hospital|The Catholic University of Korea | Chiwindi C | February 2016 | Gawo 4 |
| NCT02104843 | Bristol-Myers Squibb | Chiwindi C | Epulo 2014 | Gawo 1 |
| NCT01428063 | Bristol-Myers Squibb | Matenda a Hepatitis C Virus | Seputembara 2011 | Gawo 2 |
| NCT02123654 | Bristol-Myers Squibb | Matenda a Hepatitis C Virus | Epulo 2014 | Gawo 3 |
| NCT02565862 | Yunivesite ya Radboud | Hepatitis C | Diabetes Mellitus | Kukana insulini | Januware 2016 | Gawo 1 |
| NCT04211844 | Yunivesite ya Ain Shams | Matenda a Chiwindi C | October 1, 2019 |
|
| NCT00874770 | Bristol-Myers Squibb | Matenda a Hepatitis C | June 2009 | Gawo 2 |
| NCT03883698 | Sanjay Gandhi Postgraduate Institute of Medical Sciences | Kulephera kwa Impso, Kusatha | Chiwindi C | Marichi 15, 2019 | Gawo 3 |
| NCT01448044 | Bristol-Myers Squibb | Chiwindi C | December 2011 | Gawo 3 |
| NCT01359644 | Bristol-Myers Squibb | Pharmacset | Matenda a Chiwindi C | June 2011 | Gawo 2 |
| NCT01842451 | Malingaliro a kampani Vertex Pharmaceuticals Incorporated | Matenda a Chiwindi C|CHC|HCV|Chiwindi Chachiwindi C | June 2013 | Gawo 2 |
| NCT02762448 | Chipatala cha Tainan Municipal | Chiwindi c | July 2016 |
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| NCT02473211 | Humanity and Health Research Center|Beijing 302 Hospital | Matenda a Hepatitis C osatha | Januware 2015 | Gawo 2 | Gawo 3 |
| NCT01455090 | Bristol-Myers Squibb | Matenda a Chiwindi C | Novembala 30, 2011 | Gawo 2 |
| NCT03490097 | Yunivesite ya Ain Shams | Chronic Hepatitis c|Metabolic Syndrome | Disembala 1, 2017 | Gawo 2 | Gawo 3 |
| NCT01170962 | Bristol-Myers Squibb | Hepatitis C Virus | Ogasiti 2010 | Gawo 2 |
| NCT02333292 | Chipatala cha Valme University|Chipatala cha SAS de Jerez|Chipatala cha General Universitario Elche|Chipatala Chipatala General Universitario de Alicante|Chipatala cha Universitario Araba|Chipatala Royo Vilanova|Chipatala cha Universitario de Burgos|Complejo Hospitalario Universitario de Huelva|Chipatala cha Universitario Reina Sofia de Cordoba|Chipatala cha Universitario Virgen Macarena | Universidad de Cordoba Navarra|Chipatala Clinico Universitario San Cecilio|Chipatala Universitario La Fe|Chipatala General Universitario de Valencia|Chipatala Universitario Infanta Leonor|Chipatala Universitario de Gran Canaria|Chipatala General Universitario Santa Lucía|Centro Penitenciario Hospital Chipatala cha Alicante la Luz|Chipatala General Universitario de Castellón|Chipatala Parc Taulí, Sabadell | Matenda a Hepatitis C osatha | December 2014 |
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| NCT03200184 | Tehran University of Medical Sciences | Chiwindi C | Seputembara 1, 2016 | Gawo 4 |
| NCT03188276 | Chipatala Chachitatu Chogwirizana, Sun Yat-Sen University | Matenda a Chiwindi C | February 1, 2016 | Gawo loyamba |
| NCT01830205 | Bristol-Myers Squibb | Chiwindi C | Seputembara 2012 | Gawo 1 |
Malingaliro18Ma projekiti a Quality Consistency Evaluation omwe avomereza4,ndi6mapulojekiti akuvomerezedwa.
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Kuyang'anira kwabwino kumayendera nthawi yonse ya moyo wa chinthucho kuti zitsimikizire kuti zabwino ndi zochiritsira.
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