China Dabigatran Etexilate Mesylate opanga ndi ogulitsa

Dabigatran Etexilate Mesylate

Kufotokozera Kwachidule:

Dzina la API	Chizindikiro	Kufotokozera	US DMF	EU DMF	CEP
Dabigatran Etexilate Mesylate	Anticoagulant	M'nyumba

Titumizireni imelo

Tsatanetsatane wa Zamalonda

Zolemba Zamalonda

PRODUCT DETAIL

Kufotokozera

Dabigatran etexilate mesylate (BIBR 1048MS) ndi mankhwala opangidwa pakamwa a Dabigatran. Dabigatran etexilate mesylate ali anticoagulant zotsatira ndipo ntchito prophylaxis wa venousthromboembolism ndi sitiroko chifukwa cha matenda fibrillation.

Mbiri

Kufotokozera: IC50 Mtengo: 4.5nM (Ki); 10nM(Thrombin-induced platelet aggregation) [1] Dabigatran ndi chosinthika komanso chosankha, cholunjika cha thrombin inhibitor (DTI) chomwe chikupita patsogolo pachipatala monga mankhwala ake ogwiritsira ntchito pakamwa, dabigatran etexilate. mu vitro: Dabigatran amaletsa mwa kusankha komanso mosintha kusintha kwa thrombin ya anthu (Ki: 4.5 nM) komanso kuphatikiza kwa mapulateleti opangidwa ndi thrombin (IC(50): 10 nM), pomwe sikuwonetsa zotsatira zoletsa pazinthu zina zokongoletsa mapulateleti. -Poor plasma (PPP), yoyesedwa ngati mphamvu yamkati ya thrombin (ETP) inali yoletsedwa kudalira (IC (50): 0.56 microM). Dabigatran adawonetsa zotsatira zodalira anticoagulant m'mitundu yosiyanasiyana mu vitro, kuwirikiza kawiri nthawi ya thromboplastin (aPTT), nthawi ya prothrombin (PT) ndi nthawi ya ecarin clotting (ECT) mu PPP yaumunthu pamagulu a 0.23, 0.83 ndi 0.18 microM, motsatira [ 1]. mu vivo: Dabigatran adatalikitsa mlingo wa aPTT modalira pambuyo polowetsedwa m'mitsempha mu makoswe (0.3, 1 ndi 3 mg/kg) ndi anyani a rhesus (0.15, 0.3 ndi 0.6 mg/kg). Mlingo ndi nthawi yodalira anticoagulant zotsatira adawonedwa ndi dabigatran etexilate yoperekedwa pakamwa kwa makoswe ozindikira (10, 20 ndi 50 mg / kg) kapena anyani a rhesus (1, 2.5 kapena 5 mg / kg), ndi zotsatira zazikulu zomwe zimawonedwa pakati pa 30 ndi 120 min pambuyo poyang'anira, motsatana [1]. Odwala omwe amathandizidwa ndi dabigatran etexilate adakumana ndi zikwapu zochepa za ischemic (3.74 dabigatran etexilate vs 3.97 warfarin) ndi zochepa zophatikizira zotuluka m'magazi ndi zikwapu za haemorrhagic (0.43 dabigatran etexilate vs 0.99 warfarin) [odwala 10] pazaka 10. Kuyesa kwachipatala: Kuwunika kwa Pharmacokinetics ndi Pharmacodynamics ya Oral Dabigatran Etexilate mu Hemodialysis Odwala. Gawo 1

Kusungirako

Ufa	-20 ° C	3 zaka
	4°C	zaka 2
Mu zosungunulira	-80 ° C	6 miyezi
	-20 ° C	1 mwezi

Kuyesa Kwachipatala

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