Bictegravir 1611493-60-7
Kufotokozera
Bictegravir ndi novel, inhibitor yamphamvu ya HIV-1 integrase yokhala ndi IC50 ya 7.5 nM.
Mu Vitro
Bictegravir (BIC) imalepheretsa kusintha kwa chingwe ndi IC50 ya 7.5± 0.3 nm. Mogwirizana ndi kuletsa kwake kwa ntchito yotumiza strand, Bictegravir ndi inhibitor yofooka kwambiri ya 3.'-kukonza ntchito ya HIV-1 IN, yokhala ndi IC50 ya 241±51 nm. Bictegravir imapangitsa kudzikundikira kwa 2-LTR mabwalo ~ 5-fold pokhudzana ndi kuwongolera konyozedwa ndikuchepetsa kuchuluka kwa zophatikizika zenizeni m'maselo omwe ali ndi kachilombo ndi 100-fold. Bictegravir imalepheretsa kubwereza kwa HIV-1 m'maselo onse a MT-2 ndi MT-4 okhala ndi ma EC50 a 1.5 ndi 2.4 nM, motsatana. Bictegravir imasonyeza mphamvu zowononga tizilombo toyambitsa matenda m'ma CD4+ T lymphocytes ndi macrophages opangidwa ndi monocyte, ndi EC50s ya 1.5±0.3 nM ndi 6.6±4.1 nM, motsatira, zomwe zimafanana ndi zomwe zimapezedwa mu T-cell mizere[1].
MCE sinatsimikizire paokha kulondola kwa njirazi. Iwo ndi ongotchula chabe.
| Nambala ya NCT | Wothandizira | Mkhalidwe | Tsiku loyambira | Gawo |
| NCT03998176 | Yunivesite ya Nebraska | Gileadi Sayansi | HIV-1 - matenda | October 9, 2019 | Gawo 4 |
| NCT03789968 | Thomas Jefferson University|University of Maryland, College Park|Indiana University Health|The Brooklyn Hospital Center|University of Illinois ku Chicago|Nova Southeastern University|University of California, San Francisco | HIV + Edzi | Seputembara 1, 2019 | |
| NCT04249037 | Yunivesite ya Colorado, Denver | Gileadi Sayansi | HIV + Edzi | Marichi 1, 2020 | Zosafunika |
| NCT04132674 | Vancouver Infectious Diseases Center | Human Immunodeficiency Virus I Infection | Kugwiritsa Ntchito Mankhwala Osokoneza Bongo | Novembala 26, 2018 | Gawo 4 |
| NCT04054089 | Cristina Mussini|University of Modena ndi Reggio Emilia | Matenda a HIV | Seputembara 2019 | Gawo 4 |
| NCT04155554 | Azienda Ospedaliera Universitaria Senese|Catholic University of the Sacred Heart|Ospedale Policlinico San Martino|Azienda Ospedaliera San Paolo|Ospedale Amedeo di Savoia | HIV-1 - matenda | Januware 29, 2020 | Gawo 3 |
| NCT02275065 | Sayansi ya Gileadi | Kachilombo ka HIV-1 | October 2014 | Gawo 1 |
| NCT03711253 | Yunivesite ya Southern California | Kachilombo ka HIV | October 14, 2019 | Gawo 4 |
| NCT02400307 | Sayansi ya Gileadi | HIV | Epulo 17, 2015 | Gawo 1 |
| NCT03499483 | Fenway Community Health | Kupewa HIV | Januware 24, 2019 | Gawo 4 |
| NCT03502005 | Midland Research Group, Inc.|Gileadi Sciences | Human Immunodeficiency Virus | Marichi 1, 2018 | Gawo 4 |
Kapangidwe ka mankhwala
Malingaliro18Ma projekiti a Quality Consistency Evaluation omwe avomereza4,ndi6mapulojekiti akuvomerezedwa.
Dongosolo lotsogola lapadziko lonse lapansi loyang'anira bwino layala maziko olimba pakugulitsa.
Kuyang'anira kwabwino kumayendera nthawi yonse ya moyo wa chinthucho kuti zitsimikizire kuti zikuyenda bwino komanso zochiritsira.
Gulu la Professional Regulatory Affairs limathandizira zofunikira pakufunsira ndikulembetsa.
Korea Countec Bottled Packaging Line
Taiwan CVC Bottled Packaging Line
Italy CAM Board Packaging Line
German Fette Compacting Machine
Japan Viswill Tablet Detector
Chipinda chowongolera cha DCS
