Vericiguat ndipyrazolopyridinekuti5-fluoro-1H-pyrazolo[3,4-b]pyridinemomwe amino hydrogen pamalo 1 asinthidwa ndi gulu la 2-fluorobenzyl ndihaidrojenipa malo 3 alowetsedwa ndi 4,6-diamino-5--[(methoxycarbonyl)amino]pyrimidin-2-yl gulu. Ndi chosungunukaguanylatecyclase stimulator yomwe imagwiritsidwa ntchito pochiza kulephera kwa mtima kwanthawi yayitali. Lili ndi ntchito ngati sungunukaguanylatecyclase activator, vasodilator wothandizira ndi antihypertensive wothandizira. Ndiaminopyrimidine,apyrazolopyridine, carbamate ester ndi gulu la organofluorine.

Vericiguat akufufuzidwa mu mayesero a zachipatala NCT02861534 (Phunziro la Vericiguat mwa Omwe Ali ndi Kulephera kwa Mtima Ndi Kuchepa Kwa Ejection Fraction (HFrEF) (MK-1242-001)).

Vericiguat ndi solubleGuanylateCyclase Stimulator. Njira yogwirira ntchito ya vericiguat ili ngati aGuanylateCyclase Stimulator.

Vericiguat ndi mankhwala omwe amagwiritsidwa ntchito pochiza ndi kuchiza kulephera kwa mtima ndi kagawo kakang'ono ka ejection (HFrEF). Ndi zothandiza aakulu kuipiraipira mtima kulephera, posachedwapa decompensated mtima kulephera. Vericiguat siyitalikitsa kupulumuka koma imalepheretsa kuchira. Ntchitoyi ikuwonetsa zisonyezo, momwe amagwirira ntchito, mlingo, ndi njira yoyendetsera ntchito ndi gulu la akatswiri, zotsatira zoyipa, zotsutsana, ndi mayesero angapo kuti atsimikizire kuti mankhwalawa ndi othandiza mu HFrEF.