China Tofacitnib Citrate opanga ndi ogulitsa |CPF

Tofacitnib citrate

Kufotokozera Kwachidule:

Dzina la API	Chizindikiro	Kufotokozera	US DMF	EU DMF	CEP
Tofacitnib citrate	Matenda a nyamakazi	M'nyumba

Titumizireni imelo

Tsatanetsatane wa Zamalonda

Zolemba Zamalonda

PRODUCT DETAIL

Mbiri

Tofacitinib citrate, yomwe imadziwikanso kuti CP-690550 citrate, ndi inhibitor yamphamvu ya janus kinase 3 (JAK3), tyrosine kinase yoletsa maselo a hematopoetic yomwe imakhudzidwa ndi kufalikira kwa ma siginecha omwe amayang'anira kupulumuka kwa lymphocyte, kuchulukana, kusiyanitsa, ndi apoptosis.Cholepheretsa ndi JAK3 yeniyeni ndi kusankha 1000-kuchuluka kuposa ena omwe si a JAK family kinases.Kupatula kuletsa JAKS (IC50 = 1 nM), tofacitinib citrate imalepheretsanso janus kinase 2 (JAK2) ndi janus kinase 1 (JAK1) ndi 20- ndi 100-fold zochepa mu potency motsatira.Komabe, mu kafukufuku waposachedwa, ma affinities (Ki) omangirira (Ki) a tofacitinib citrate ku JAK1, JAK2, ndi JAK3 adanenedwa kukhala 1.6 nM, 21.7 nM, ndi 6.5 nM motsatana.

Buku

Lalitha Vijayakrishnan, R. Venkataramanan and Palak Gulati.Kuchiza kutupa ndi janus kinase inhibitor CP-690,550.Zochitika mu Pharmacological Sciences 2011: 32 (1);25-34

Product Citation

1. Panagi I, Jennings E, et al."Salmonella Effector SteE Imasintha Mammalian Serine/Threonine Kinase GSK3 kukhala Tyrosine Kinase kukhala Direct Macrophage Polarization."Cell Host Microbe.2020;27(1):41–53.e6.PMID: 31862381
2. McInnes IB, Byers NL, et al."Kuyerekeza kwa baricitinib, upadacitinib, ndi tofacitinib mediated regulation of cytokine signing in human leukocyte subpopulations."Matenda a Nyamakazi Amakhala Ku Ther.2019 Aug 2; 21(1): 183.PMID: 31375130
3. Liu S, Verma M, et al."Steroid resistance of airway type 2 innate lymphoid cells from odwala omwe ali ndi mphumu yoopsa: Udindo wa thymic stromal lymphopoietin." J Allergy Clin Immunol.2018 Jan; 141 (1): 257-268.e6.PMID: 28433687
4. Zheng, Lufeng, et al."3' UTR ya pseudogene CYP4Z2P imalimbikitsa chotupa angiogenesis mu khansa ya m'mawere pochita ngati ceRNA ya CYP4Z1."Kafukufuku wa khansa ya m'mawere ndi chithandizo (2015): 1-14.PMID: 25701119

Kufotokozera

Tofacitinib citrate ndi JAK1/2/3 inhibitor yopezeka pakamwa yokhala ndi IC50s ya 1, 20, ndi 112 nM, motsatana.Tofacitinib citrate ali ndi antibacterial, antifungal ndi antiviral ntchito.

Kusungirako

4 ° C, tetezani ku kuwala

*Mu zosungunulira : -80°C, miyezi 6;-20°C, mwezi umodzi (chitetezo ku kuwala)