Kufotokozera

Rosuvastatin Calcium (BANM, JAN, USAN) amadziwika kuti Rosuvastatin ku US. ndi mpikisano wa HMG-CoA reductase inhibitor wokhala ndi IC50 ya 11 nM[1]. Rosuvastatin Calcium imatsekereza jini yokhudzana ndi ether-a-go-go (hERG) yaposachedwa ndi IC50 ya 195 nM, kuchedwa kuyambiranso kwa mtima, ndipo potero kuchitapo kanthu kwanthawi yayitali (APDs) ndikuwongolera kagawo ka QT (QTc)[2]. Rosuvastatin Calcium imachepetsa kufotokozera kwa hERG yokhwima komanso kuyanjana kwa mapuloteni a kutentha kwa 70 (Hsp70) ndi mapuloteni a hERG. Kashiamu ya Rosuvastatin ndiyothandiza kwambiri potsitsa mafuta otsika kwambiri a lipoprotein (LDL), triglycerides, ndi ma protein a C-reactive [3].

Zambiri pamisonkhano yotchula mayina amankhwala: Mayina Osavomerezeka Padziko Lonse.

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Ku US, Rosuvastatin (rosuvastatin systemic) ndi membala wa gulu la mankhwala a statins ndipo amagwiritsidwa ntchito pochiza Atherosclerosis, High Cholesterol, High Cholesterol - Familial Heterozygous, High Cholesterol - Homozygous Family, Hyperlipoproteinemia, Hyperlipoproteinemia Type IIa - Okwera LDL, Hyperlipopro IIb - okwera LDL VLDL, Hyperlipoproteinemia Type III - Okwera beta-VLDL IDL, Hyperlipoproteinemia Type IV - VLDL yokwera, Hypertriglyceridemia ndi Kupewa Matenda a Mtima.

Mbiri

Choletsa chosankha, chopikisana cha HMG-CoA reductase, chomwenso ndi antilipidemic.

Kusungirako

Kapangidwe ka mankhwala