Pregabalin

Kufotokozera Kwachidule:

Dzina la API Chizindikiro Kufotokozera US DMF EU DMF CEP
Pregabalin Khunyu/Neuralgia M'nyumba/EP 22223 CEP2016-141


Tsatanetsatane wa Zamalonda

Zolemba Zamalonda

PRODUCT DETAIL

Pregabalin si GABAA kapena GABAB receptor agonist.
Pregabalin ndi gabapentinoid ndipo amagwira ntchito poletsa njira zina za calcium. Makamaka ndi ligand wa malo othandizira a α2δ subunit ya njira zina za calcium zodalira mphamvu (VDCCs), ndipo potero amakhala ngati inhibitor ya α2δ subunit-containing VDCCs. Pali zigawo ziwiri za α2δ zomangira mankhwala, α2δ-1 ndi α2δ-2, ndipo pregabalin imasonyeza kuyanjana kofanana kwa (ndi chifukwa chake kusowa kwa kusankha pakati) malo awiriwa. Pregabalin imasankha pomanga gawo la α2δ VDCC. Ngakhale kuti pregabalin ndi GABA analogue, sichimangirira ku GABA receptors, sichisintha kukhala GABA kapena GABA receptor agonist mu vivo, ndipo sichimayendetsa mwachindunji kayendedwe ka GABA kapena kagayidwe kake. Komabe, pregabalin yapezeka kuti ikupanga kuwonjezereka kodalira mlingo wa L-glutamic acid decarboxylase (GAD), enzyme yomwe imayambitsa kupanga GABA, motero ikhoza kukhala ndi zotsatira zina za GABAergic mwa kuonjezera milingo ya GABA mu ubongo. Pakalipano palibe umboni wosonyeza kuti zotsatira za pregabalin zimayendetsedwa ndi njira ina iliyonse kupatula kuletsa kwa α2δ-containing VDCCs. Mogwirizana, kuletsa kwa α2δ-1-containing VDCCs ndi pregabalin kumawoneka kuti kumayambitsa anticonvulsant, analgesic, ndi anxiolytic zotsatira.
Ma endogenous α-amino acids L-leucine ndi L-isoleucine, omwe amafanana kwambiri ndi pregabalin ndi ma gabapentinoids ena pamapangidwe amankhwala, ndi ma ligand a subunit ya α2δ VDCC yokhala ndi mgwirizano wofanana ndi ma gabapentinoids (mwachitsanzo, IC50 = 71 nM ya L- isoleucine), ndipo amapezeka mu cerebrospinal fluid ya munthu pa micromolar ndende (mwachitsanzo, 12.9 μM kwa L-leucine, 4.8 μM kwa L-isoleucine). Zakhala zikunenedwa kuti akhoza kukhala ma ligands amtundu wa subunit komanso kuti akhoza kupikisana ndi zotsatira za gabapentinoids. Mogwirizana, pamene ma gabapentinoids monga pregabalin ndi gabapentin ali ndi ma nanomolar affinities a α2δ subunit, mphamvu zawo mu vivo zili m'gulu lotsika la micromolar, ndipo mpikisano womanga ndi L-amino acids wanenedwa kuti ndiwo amachititsa kusiyana kumeneku.

Pregabalin adapezeka kuti ali ndi 6-fold high kuyanjana kuposa gabapentin kwa α2δ yokhala ndi ma VDCC a subunit mu kafukufuku wina. Komabe, kafukufuku wina adapeza kuti pregabalin ndi gabapentin anali ndi zofanana zofanana ndi α2δ-1 subunit yamunthu (Ki = 32 nM ndi 40 nM, motsatana). Mulimonsemo, pregabalin imakhala yamphamvu 2 mpaka 4 kuposa gabapentin ngati mankhwala ochepetsa ululu ndipo, mwa nyama, imawoneka kuti ili ndi mphamvu 3 mpaka 10 kuposa gabapentin ngati anticonvulsant.

CERTIFICATE

2018 GMP-2
原料药GMP证书201811 (captopril,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

KUSINTHA KWA KHALIDWE

Kasamalidwe kabwino 1

Malingaliro18Ma projekiti a Quality Consistency Evaluation omwe avomereza4,ndi6mapulojekiti akuvomerezedwa.

Kasamalidwe kabwino2

Dongosolo lotsogola lapadziko lonse lapansi loyang'anira bwino layala maziko olimba pakugulitsa.

Kasamalidwe kabwino3

Kuyang'anira kwabwino kumayendera nthawi yonse ya moyo wa chinthucho kuti zitsimikizire kuti zikuyenda bwino komanso zochiritsira.

Kasamalidwe kabwino4

Gulu la Professional Regulatory Affairs limathandizira zofunikira pakufunsira ndikulembetsa.

MANAGEMENT ZOPHUNZITSA

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Taiwan CVC Bottled Packaging Line

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Japan Viswill Tablet Detector

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Chipinda chowongolera cha DCS

WOTHANDIZA

Mgwirizano wapadziko lonse lapansi
Mgwirizano wapadziko lonse lapansi
Mgwirizano wapakhomo
Mgwirizano wapakhomo

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