Pomalidomide, yomwe poyamba inkadziwika kuti CC-4047 kapena actimid, ndi molekyulu yamphamvu ya immunomodulatory yomwe imawonetsa ntchito ya antiineoplastic pochiza matenda a hematological malignancies, makamaka omwe abwereranso komanso osasinthika angapo a myeloma (MM). Monga chochokera ku thalidomide, pomalidomide ili ndi mankhwala ofanana ndi thalidomide kupatulapo kuwonjezera magulu awiri a oxo mu mphete ya phthaloyl ndi gulu la amino pa malo achinayi. Nthawi zambiri, monga molekyulu ya immunomodulatory, pomalidomide imawonetsa antitumor ntchito pogwiritsa ntchito njira yotsekereza microenvironment ya chotupa posintha ma cytokines othandizira chotupa (TNF-α, IL-6, IL-8 ndi VEGF), kuwongolera mwachindunji ntchito zazikulu za chotupa. ma cell, komanso kuthandizira kuchokera ku ma cell omwe alibe chitetezo chamthupi.

Pomalidomide amagwiritsidwa ntchito pochiza myeloma yambiri (khansa yobwera chifukwa cha matenda opitilira magazi). Pomalidomide amaperekedwa pambuyo poti mankhwala ena osachepera awiri ayesedwa osapambana.

Pomalidomide amagwiritsidwanso ntchito pochiza Kaposi sarcoma yokhudzana ndi Edzi pamene mankhwala ena sanagwire ntchito kapena kusiya kugwira ntchito. Pomalidomide itha kugwiritsidwanso ntchito pochiza Kaposi Sarcoma mwa akuluakulu omwe aliHIV- zoipa.

Pomalidomide imapezeka kokha ku pharmacy yovomerezeka pansi pa pulogalamu yapadera. Muyenera kulembetsedwa mu pulogalamuyi ndikuvomera kugwiritsa ntchitokuleramiyeso ngati pakufunika.

Pomalidomide itha kugwiritsidwanso ntchito pazinthu zomwe sizinalembedwe mu bukhuli lamankhwala.

Pomalidomide ikhoza kuyambitsa zilema zowopsa, zoyika moyo wakhanda kapena imfa ya mwana ngati mayi kapena bambo akumwa pomalidomide pa nthawi yoyembekezera kapena ali ndi pakati. Ngakhale mlingo umodzi wa pomalidomide ungayambitse vuto lalikulu la manja ndi miyendo, mafupa, makutu, maso, nkhope, ndi mtima wa mwanayo. Musagwiritse ntchito pomalidomide ngati muli ndi pakati. Uzani dokotala wanu nthawi yomweyo ngati nthawi yanu yachedwa mukamamwa pomalidomide.