Pitavastatin Calcium
| 匹伐他汀钙 | Pitavastatin | 147526-32-7 | M'nyumba |
| PI-5 | 3800-06-4 | M'nyumba | |
| PI-6 | 145516-11-4 | M'nyumba | |
| PI-7 | 121660-11-5 | M'nyumba |
Kufotokozera
Pitavastatin Calcium (NK-104 hemicalcium) ndi amphamvu hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) imalepheretsa kaphatikizidwe ka cholesterol kuchokera ku acetic acid ndi IC50 ya 5.8 nM m'maselo a HepG2. Pitavastatin Calcium ndi hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Ntchito yolimbana ndi khansa.
Mbiri
Pitavastatin Calcium ndi mpikisano woletsa enzyme HMGCR (HMG-CoA reductase) imapangitsa kuchepa kwa kaphatikizidwe ka LDL cholesterol. Kafukufuku wina akuwonetsa kuti pitavastatin imatha kupondereza kupanga okosijeni m'maselo a endothelial poletsa NADPH oxidase. Kuphatikiza apo, pitavastatin imachepetsa mawu a eNOS mRNA pomwe imakulitsa kuyankha kodalira NO komwe kumalimbikitsidwa ndi acetylcholine ndi calcium ionophore, A23187. Kuphatikiza apo, pitavastatin imalepheretsa kuwongolera kwa njira za potaziyamu yolumikizidwa ndi calcium pochepetsa kuchuluka kwa cholesterol m'maselo.
Kusungirako
4°C, kuteteza ku kuwala
*Mu zosungunulira: -80°C, miyezi 6; -20°C, mwezi umodzi (chitetezo ku kuwala)
Kapangidwe ka mankhwala
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