2. Thalidomide mu chotupa cachexia
Oncologic cachexia, khansa yapamwamba yodziwika ndi anorexia, kuchepa kwa minofu ndi kuchepa thupi, ndizovuta kwambiri pakusamalira khansa yapamwamba.
Chifukwa chakukhala ndi moyo kwakanthawi kochepa komanso kutsika kwa moyo wa odwala omwe ali ndi khansa yapamwamba, chiwerengero cha maphunziro azachipatala ndi chochepa, ndipo maphunziro ambiri amangowona momwe thalidomide imathandizira kwambiri komanso zotsatira zake za nthawi yayitali. Kugwira ntchito kwanthawi yayitali komanso zovuta zanthawi yayitali za thalidomide pochiza oncologic cachexia ziyenera kufufuzidwabe m'mayesero azachipatala okhala ndi zitsanzo zazikulu.
3. Zotsatira zoyipa zokhudzana ndi chithandizo cha thalidomide
Zotsatira zoyipa monga nseru wokhudzana ndi chemotherapy ndi kusanza zimatha kusokoneza mphamvu ya mankhwala amphamvu komanso kuchepetsa moyo wa odwala. Ngakhale kuti otsutsa a neurokinin 1 receptor antagonists amatha kusintha kwambiri zotsatira zoyipa monga nseru ndi kusanza, kugwiritsa ntchito kwawo kuchipatala ndi kupititsa patsogolo kumakhala kovuta chifukwa chachuma cha odwala komanso zifukwa zina. Choncho, kufufuza mankhwala otetezeka, ogwira ntchito komanso otsika mtengo kuti ateteze ndi kuchiza nseru ndi kusanza kokhudzana ndi chemotherapy wakhala vuto lachipatala mwamsanga.
4. Mapeto
Ndi chitukuko chosalekeza cha kafukufuku woyambira komanso wachipatala, kugwiritsa ntchitothalidomidepochiza zotupa zolimba wamba zakhala zikukulirakulira, ndipo mphamvu yake yachipatala ndi chitetezo zazindikirika ndikupereka njira zatsopano zothandizira odwala. Thalidomide imathandizanso pochiza chotupa cachexia ndi chemotherapy-kugwirizana ndi nseru ndi kusanza. M'nthawi yamankhwala ochiritsira olondola, ndikofunikira kuyang'ana kuchuluka kwa anthu omwe ali ndi zotupa zomwe zimagwira ntchito bwino.thalidomidechithandizo ndikupeza ma biomarkers omwe amalosera zamphamvu zake komanso zotsatira zake zoyipa.