Ruxolitinib ndi mtundu wamankhwala omwe amayang'aniridwa pakamwa otchedwa kinase inhibitor ndipo amagwiritsidwa ntchito makamaka pochiza matenda monga graft-versus-host disease, erythroblastosis, ndi myelofibrosis yapakati komanso yoopsa kwambiri, pamene Ruxolitinib kirimu ndi mankhwala a dermatological omwe amagwiritsidwa ntchito. mwachindunji pakhungu kuchiza chikanga, vitiligo, atopic dermatitis, ndi dazi. Ngakhale Ruxolitinib ndi Ruxolitinib zonona ndizosiyana kwambiri wina ndi mzake, amasokonezeka mosavuta chifukwa ali ndi dzina lofanana. Changzhou Pharmaceutical Factory (CPF), wotsogoleraWopereka Ruxolitinibku China, apa kusanthula kusiyana pakati pawo mwa mawu a mbali zazikulu zitatu kukuthandizani kudziwa zambiri za iwo.
1. Chizindikiro
Ruxolitinibidavomerezedwa ndi FDA mu Novembala 2011 komanso ndi European Commission mu Ogasiti 2012 ndipo ndi mtundu wamankhwala omwe amawunikidwa omwe ali ndi zizindikiro zotsimikizika. Amagwiritsidwa ntchito pochiza odwala omwe ali ndi mitundu itatu ya matenda, kuphatikizapo steroid-refractory acute graft-versus-host disease, erythroblastosis, ndi moderate-to-high risk myelofibrosis (MF). Koma Ruxolitinib kirimu ali mu gawo lachitukuko ndipo amalephera kupita kumsika, kotero ndi mankhwala apakhungu ochizira matenda a shin ndi dazi ndipo alibe zovomerezeka panobe. Komabe, kafukufuku wasonyeza kupambana kwa Ruxolitinib kirimu pochiza vitiligo, atopic dermatitis ndi dazi lalikulu.
2. Njira yogwiritsira ntchito
Ruxolitinib ndi oral kinase inhibitor yomwe imakhala ngati inhibitor yaing'ono ya molecule ya protein kinases JAK1 ndi JAK2, ndipo ndi mankhwala oyamba omwe amavomerezedwa ndi FDA kuti athetse myelofibrosis. Koma zonona za Ruxolitinib ndi zonona zapamutu zomwe zimasiyana kwambiri ndi Ruxolitinib momwe zimagwiritsidwira ntchito.
3. Zotsatira zake
Ruxolitinib imakhala ndi zotsatirapo zomveka. Zotsatira zodziwika bwino za hematologic zomwe zimagwirizanitsidwa ndi kugwiritsidwa ntchito kwake ndi kuchepa kwa chiwerengero cha mapulateleti ndi kuchepa kwa magazi m'thupi, ndipo zotsatira zosagwirizana ndi hematologic ndi petechiae, chizungulire, ndi mutu. Komabe, kirimu cha Ruxolitinib chikadali m'mayesero azachipatala, kotero zotsatira zake sizidziwika.
Lumikizanani ndi CPF kuti mutenge Ruxolitinib pamtengo wotsika mtengo, ndikupita nawo ku kampeni yolemba anthu zachipatala kuti mupeze Ruxolitinib kirimu kwaulere.
Nthawi yotumiza: May-12-2022