Ruxolitinib, yomwe imadziwikanso kuti ruxolitinib ku China, ndi imodzi mwa "mankhwala atsopano" omwe atchulidwa kwambiri m'mabuku otsogolera ochizira matenda a hematological m'zaka zaposachedwa, ndipo awonetsa kuti ali ndi mphamvu zowonjezera matenda a myeloproliferative.
Mankhwala omwe akuwongolera Jakavi ruxolitinib amatha kuletsa kutsegulira kwa njira yonse ya JAK-STAT ndikuchepetsa chizindikiro chowonjezereka cha njirayo, motero kuchita bwino.Itha kugwiritsidwanso ntchito pochiza matenda osiyanasiyana, komanso zovuta zapatsamba la JAK1.
Ruxolitinibndi kinase inhibitor yomwe imasonyezedwa pochiza odwala omwe ali ndi myelofibrosis yapakati kapena yoopsa kwambiri, kuphatikizapo primary myelofibrosis, post-geniculocytosis myelofibrosis, ndi post-primary thrombocythemia myelofibrosis.
Kafukufuku wofananira wachipatala (n = 219) odwala omwe ali ndi vuto lapakati-2 kapena chiopsezo chachikulu cha MF, odwala omwe ali ndi MF pambuyo pa erythroblastosis yeniyeni, kapena odwala omwe ali ndi MF pambuyo pa thrombocytosis yoyamba m'magulu awiri, mmodzi akulandira oral ruxolitinib 15 mpaka 20 mgbid. (n=146) ndipo winayo akulandira mankhwala owongolera (n=73).Mfundo zazikuluzikulu ndi zofunikira zachiwiri za phunziroli zinali kuchuluka kwa odwala omwe ali ndi ≥35% kuchepa kwa voliyumu ya ndulu (yoyesedwa ndi kujambula kwa maginito kapena computed tomography) pamasabata 48 ndi 24 motsatira.Zotsatira zinasonyeza kuti chiwerengero cha odwala omwe ali ndi 35% kuchepetsa kuchuluka kwa ndulu kuyambira pachiyambi pa sabata 24 anali 31.9% mu gulu lachipatala poyerekeza ndi 0% mu gulu lolamulira (P <0.0001);ndipo chiwerengero cha odwala omwe ali ndi 35% kuchepetsa kuchuluka kwa ndulu kuchokera pachiyambi pa sabata 48 anali 28.5% mu gulu lachipatala poyerekeza ndi 0% mu gulu lolamulira (P <0.0001).Kuphatikiza apo, ruxolitinib idachepetsanso zizindikiro zonse ndikuwongolera kwambiri moyo wa odwala.Kutengera zotsatira za mayeso achipatala awiriwa,ruxolitinibadakhala mankhwala oyamba ovomerezedwa ndi US FDA pochiza odwala omwe ali ndi MF.