Ruxolitinibndi mtundu wa mankhwala a khansa omwe amawatsata.Amagwiritsidwa ntchito makamaka kuletsa kutsegulira kwa njira yowonetsera ya JAK-STAT ndikutsitsa chizindikiro chomwe chimalepheretsa kupititsa patsogolo kwachilendo, motero kupeza chithandizo chamankhwala.Zimagwira ntchito polepheretsa thupi lanu kupanga zinthu zomwe zimatchedwa kukula.Sizingachiritse matenda amodzi okha m'dera la mankhwala a hematology, komanso kuchitiranso ma neoplasms akale a myeloproliferative (amatchedwanso BCR-ABL1-negative MPNs), JAK exon 12 mutations, CALR, ndi APL, ndi zina zotero.
Kodi mlingo woyambira wovomerezeka ndi uti?
Zitha kuyambitsa zotsatira zoyipa kuphatikiza myelosuppression komanso, zomwe zimapangitsa kuti pakhale mawonekedwe osowa, koma owopsa azachipatala monga neutropenia, thrombocytopenia, leukemia ndi anemia.Choncho kusamala kwambiri kuyenera kuchitidwa pozindikira mlingo woyambira popereka mankhwala kwa odwala.Mlingo woyambira wa Ruxolitinib umatengera kuchuluka kwa PLT kwa wodwalayo.Kwa odwala omwe kuchuluka kwa mapulateleti kumapitilira 200, mlingo woyambira ndi 20 mg kawiri tsiku lililonse;kwa omwe ali ndi chiwerengero cha mapulateleti m'kati mwa 100 mpaka 200, mlingo woyambira ndi 15 mg kawiri tsiku lililonse;Kwa odwala omwe ali ndi chiwerengero cha mapulateleti pakati pa 50 ndi 100, mlingo waukulu woyambira ndi 5 mg kawiri tsiku lililonse.
Njira zodzitetezera musanatengeRuxolitinib
Choyamba, kusankha dokotala wolemera zinachitikira mankhwala ndi Ruxolitinib.Uzani dokotala wanu ngati muli ndi ziwengo, kapena ngati muli ndi ziwengo zina zilizonse.Itha kukhala ndi zosakaniza zomwe sizikugwira ntchito, zomwe zingayambitse kusamvana kapena zovuta zina.
Kachiwiri, yesani kuchuluka kwa PLT yanu pafupipafupi.Kuwerengera kwathunthu kwa magazi ndi kuwerengera kwa mapulateleti kuyenera kulembedwa pakadutsa milungu 2-4 kuyambira kumwa Ruxolitinib mpaka Mlingo utakhazikika, ndiyeno kuyezetsa ngati zizindikiro zachipatala zikufunika.
Chachitatu, sinthani Mlingo moyenera.Mlingo woyambira susinthidwa kawirikawiri ngati mutenga Ruxolitinib koma kukhala ndi chiwerengero chochepa cha mapulateleti poyambira.Pamene chiwerengero chanu cha PLT chikukwera pamene chithandizo chogwirizanitsa chikukwera, mukhoza kuwonjezera mlingo wanu pang'onopang'ono potsatira malangizo a dokotala mosamala.
Pomaliza, auzeni dokotala mbiri yanu yachipatala, makamaka ya matenda a myeloproliferative monga matenda a impso, matenda a chiwindi, ndi khansa yapakhungu.Mankhwala ena kapena mankhwala ayenera kulowa m'malo mwa Ruxolitinib ngati simuli oyenera.
Nthawi yotumiza: Apr-25-2022