M'zaka zaposachedwapa, malonda aapixabanzakula mofulumira, ndipo msika wapadziko lonse wadutsa kalerivaroxaban.Chifukwa Eliquis (apixaban) ali ndi mwayi kuposa warfarin popewa sitiroko ndi magazi, ndi Xarelto (Rivaroxaban) amangosonyeza kuti sanali otsika.Kuphatikiza apo,Apixabansikutanthauza kusintha kwa mlingo movutirapo, ndipo mankhwalawo ndiwosavuta.Izi mndandanda wa kuipa anayambitsarivaroxabankutaya malo pamsika waku US.

Komabe, ku China,rivaroxabanali ndi zizindikiro zambiri padziko lonse lapansi komanso ku China.Patent nthawi yotsiriza yarivaroxabanali pafupi, ndipo kupezeka kwa mankhwalawa kudzachititsa anthu ambiririvaroxabanmankhwala generic kuposa kwambiriApixaban.

Malinga ndi data ya Xianda, malonda amsika wa rivaroxaban mu 2018 anali 2.8 biliyoni.Malinga ndi chilengezo cha Huahai Pharmaceutical, chipatala chapakhomo malonda msika warivaroxabanmu 2018 anali 1.527 biliyoni yuan.

Zachidziwikire, kulembedwa kwamankhwala amtundu uliwonse kudzetsa kutsika kwakukulu kwa mtengo watsiku limodzi warivaroxaban.Poganizira kuti pakati pa ma NOAC onse, ma patent arivaroxabanmankhwala amatha mu 2020 koyambirira (mapatent aapixabanndi dabigatran etexilate ndi yayitali Kwa nthawi yayitali), mosakayika zidzakhala zopindulitsa pakukweza kwathunthu kwarivaroxabanmankhwala generic m'malo mwa warfarin.Ngati mtengo watsiku ndi tsiku warivaroxabanmankhwala a generic amayambitsidwa kuchokera ku 27.6 yuan mpaka 2.76 yuan, izi zilimbikitsidwanso.

Chiwerengero cha mapulogalamu omwe amangoganizira za odwala omwe ali ndi matenda a atrial fibrillation (AF) nawonso ndi odabwitsa.Chiwerengero cha odwala ndi fibrillation ya atria ku China ndi pafupifupi 10 miliyoni, omwe pafupifupi 2 miliyoni ndi a valvular atrial fibrillation ndi pafupifupi 7 miliyoni a non-valvular atria fibrillation.Kafukufuku mu 2016 adapeza kuti kuchuluka kwa chidziwitso cha matenda a atrial fibrillation ku Mainland China ndi 40%, ndipo anticoagulation rate ndi 30%.Rivaroxaban ndiyosavuta kugwiritsa ntchito, sikutanthauza kuwunika pafupipafupi kwa zizindikiro za coagulation, komanso kuchuluka kwa anticoagulation kudzakhalanso bwino kwambiri.Amanenedweratu kuti mankhwala generic warivaroxabanadzakhala ku Mainland China.Kukula kwa msika komwe kumagwiritsidwa ntchito kwa odwala omwe ali ndi vuto lopanda valvular atrial fibrillation ndi fibrillation ya atria: odwala 7 miliyoni * 30% anticoagulation rate * 50% malowedwe * 2.76 yuan/tsiku * 365 days = 157 miliyoni yuan.

Kuphatikiza apo, chiyembekezo chamsika chopewera ndi kuchiza odwala a VTE chikucheperachepera.Malinga ndi ziwerengero za VTE Prevention and Treatment Center ku United States, chiwerengero cha odwala VTE ku United States ndi 900,000 chaka chilichonse, ndipo chiwerengero cha anthu omwe amamwalira ndi VTE chimafika 60,000 mpaka 100,000, ndipo alipo. zovuta za nthawi yayitali (Monga DVT) odwala amawerengera 50%, ndipo chiwerengero cha kubwereranso mkati mwa zaka 10 chinali 33%.

Chifukwa cha ukalamba wa anthu aku China, ndipo chiwerengero cha anthu ndi choposa 4 ku United States (anthu 1.395 biliyoni).Zitha kunenedweratu kuti pali odwala 3.6 miliyoni a VTE ku China chaka chilichonse.Kungoganiza kuti 3-mwezi mankhwala mlingo warivaroxabanndi 80%, kukula kwa msika ndi: odwala 3.6 miliyoni * 80% mlingo wa chithandizo * 2.76 yuan/tsiku * masiku 92 = 731 miliyoni yuan.

Chifukwa chake, pongowerengera zisonyezo ziwiri za AF ndi VTE, kukula kwa msika wamsika wamankhwala amtundu wa rivaroxaban kuli pafupi ndi 2 biliyoni ya yuan.Ndikokwanira kupangitsa makampani opanga mankhwala apakhomo kuthamangira kulembetsa mndandanda.

Ife,Changzhou Pharmaceutical Factory, komanso kupangaapxiabanndirivaroxban, ndipo onse ali ndi DMF.Rivaroxabanikukonzekera kugwiritsa ntchito CEP ndi WC.