Kufotokozera

Hydrochlorothiazide (HCTZ), mankhwala okodzetsa pakamwa a gulu la thiazide, amalepheretsa kusintha kwa TGF-β/ Njira yolumikizirana ndi Smad. Hydrochlorothiazide imakhala ndi zotsatira zotsitsimula mwachindunji kudzera pakutsegula njira ya calcium-activated potaziyamu (KCA). Hydrochlorothiazide imathandizira kugwira ntchito kwa mtima, imachepetsa fibrosis komanso imakhala ndi antihypertensive effect.

Mbiri

Hydrochlorothiazide ndi mankhwala okodzetsa a gulu la thiazide.

Mu Vitro

Hydrochlorothiazide ndi m'gulu la thiazide diuretics. Amachepetsa kuchuluka kwa magazi pochita impso kuti achepetse kuyamwanso kwa sodium (Na) mu distal convoluted tubule. Malo akuluakulu ochitapo kanthu mu nephron akuwonekera pa electroneutral Na + -Cl co-transporter mwa kupikisana ndi malo a chloride pa transporter. Mwa kusokoneza kayendedwe ka Na mu distal convoluted tubule, hydrochlorothiazide imapangitsa kuti natriuresis ndi kutaya madzi kofanana. Thiazides amawonjezera kuyamwanso kwa calcium mu gawo ili mosagwirizana ndi kayendedwe ka sodium. Kuphatikiza apo, ndi njira zina, Hydrochlorothiazide amakhulupirira kuti imachepetsa kukana kwa mitsempha.

Hydrochlorothiazide (HCTZ; oral bygavage; 12.5 mg/kg/d; masabata a 8) yathandiza kuti mtima ugwire ntchito bwino, kuchepetsa mtima wa interstitial fibrosis ndi kachigawo kakang'ono ka collagen, kutsika kwa AT1, TGF-β ndi Smad2 mu minyewa yamtima mwa makoswe aamuna akulu a Sprague Dawley. Kuphatikiza apo, hydrochlorothiazide imachepetsa plasma angiotensin II ndi aldosterone. Kuphatikiza apo, hydrochlorothiazide imalepheretsa angiotensin II-induced TGF-.β1 ndi Smad2 protein expression mu neonatal rat ventricular fibroblasts.

Kapangidwe ka mankhwala