Crisaborole
Crisaborole ndi membala wa gulu la benzoxaboroles lomwe ndi 5-hydroxy-1,3-dihydro-2,1-benzoxaborole momwe phenolichaidrojeniwasinthidwa ndi gulu la 4-cyanophenyl. Phosphodiesterase 4 inhibitor yomwe imagwiritsidwa ntchito pochiza dermatitis yofatsa mpaka yocheperako mwa ana ndi akulu. Ili ndi gawo ngati phosphodiesterase IV inhibitor, ndiantipsoriaticndi non-steroidal anti-yotupa mankhwala. Ndi benzoxaborole, ether wonunkhira komanso nitrile.
Crisaborole ndi bukuoxaboroleovomerezedwa ndi FDA pa Disembala 14, 2016 ngati Eucrisa, chithandizo chapamutu cha dermatitis yofatsa mpaka yolimbitsa ya atopic. Mankhwala osagwiritsa ntchito steroidal awa ndi othandiza pakuwongolera kukula kwa matenda, kuchepetsa chiopsezo chotenga matenda ndikuchepetsa zizindikiro ndi zizindikiro kwa odwala azaka ziwiri kapena kuposerapo. Amachepetsa kutupa m'deralo pakhungu ndipo amalepheretsa kuwonjezereka kwa matendawa ndi mbiri yabwino yachitetezo. Mapangidwe ake ali ndi aboroniatomu, amene facilitates khungu malowedwe ndi kumanga kwa bimetal pakati phosphodiesterase 4 enzyme. Pakali pano ikupangidwa ngati mankhwala apakhungu a psoriasis.
Crisaborole ndi Phosphodiesterase 4 Inhibitor. Limagwirira ntchito crisaborole monga Phosphodiesterase 4 Inhibitor.





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