Chlorothiazide
Mbiri
Chlorothiazide ndi inhibitor ya carbonic anhydrase ndipo ndi yocheperako pang'ono kuposa acetazolamide. Gululi lawonetsedwa kuti limalepheretsa kuyamwanso kwa ayoni a sodium ndi chloride.
Kufotokozera
Chlorothiazide ndi diuretic komanso antihypertensive. (IC50=3.8 mM) Cholinga: Ena Chlorothiazide sodium (Diuril) ndi okodzetsa omwe amagwiritsidwa ntchito m'chipatala kapena kuti agwiritse ntchito payekha kuti athetse madzi ochulukirapo omwe amadza chifukwa cha kusokonezeka kwa mtima. Amagwiritsidwanso ntchito ngati antihypertensive. Nthawi zambiri amatengedwa ngati mapiritsi, nthawi zambiri amatengedwa pakamwa kamodzi kapena kawiri patsiku. M'malo a ICU, chlorothiazide imaperekedwa kuti ikhale ndi diurese wodwala kuwonjezera pa furosemide (Lasix). Kugwira ntchito mosiyana ndi furosemide, ndikuyamwa mwachidwi ngati kuyimitsidwanso komwe kumayendetsedwa kudzera mu chubu cha nasogastric (NG chubu), mankhwalawa amatha kulimbikitsana.
Kuyesa Kwachipatala
Nambala ya NCT | Wothandizira | Mkhalidwe | Tsiku loyambira | Gawo |
NCT03574857 | Yunivesite ya Virginia | Kulephera kwa Mtima | June 2018 | Gawo 4 |
NCT02546583 | Yale University|National Heart, Lung, and Blood Institute (NHLBI) | Kulephera kwa Mtima | Ogasiti 2015 | Zosafunika |
NCT02606253 | Vanderbilt University | Vanderbilt University Medical Center | Kulephera kwa Mtima | February 2016 | Gawo 4 |
NCT00004360 | National Center for Research Resources (NCRR)|University of Northwestern University|Office of Rare Diseases (ORD) | Matenda a shuga a Insipidus, Nephrogenic | Seputembara 1995 |
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NCT00000484 | National Heart, Lung, and Blood Institute (NHLBI) | Matenda a mtima | Matenda a Mtima | Kuthamanga Kwambiri | Matenda a Mitsempha | Epulo 1966 | Gawo 3 |
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