Mbiri

Canagliflozin ndi buku, lamphamvu, komanso losankha kwambiri sodium glucose co-transporter (SGLT) 2 inhibitor [1]. Zatsimikiziridwa kuti canagliflozin imatha kuchulukitsa kuchuluka kwa shuga mkodzo mwa kuchepetsa kuchuluka kwa shuga m'magazi ndikuchepetsa kuyamwanso kwa glucose osefedwa [2].

Canagliflozin yawonetsedwa kuti imalepheretsa kulowa kwa Na+-mediated 14C-AMG mu CHO-hSGLT2, CHO-rat SGLT2 ndi CHO-mbewa SGLT2 yokhala ndi IC50 milingo ya 4.4, 3.7 ndi 2.0 nM, motsatana [1].

Canagliflozin akuti amachepetsa kuchuluka kwa shuga m'magazi (BG) motengera makoswe onse a db/db Mice ndi Zucker diabetesic fatty (ZDF). Kuphatikiza apo, canagliflozin yatsimikizira kuti imachepetsa chiwopsezo chosinthira kupuma, komanso kulemera kwa thupi mu mbewa za DIO ndi makoswe a ZDF [1].

Canagliflozin imatha kutengedwa pakamwa [1].

Zolozera:
[1] Liang Y1, Arakawa K, Ueta K, Matsushita Y, Kuriyama C Martin T, Du F, Liu Y, Xu J, Conway B, Conway J, Polidori D, Ways K, Demarest K. Zotsatira za canagliflozin pachimake aimpso kwa glucose, glycemia, ndi kulemera kwa thupi pazanyama zodziwika bwino komanso za matenda ashuga. PLoS One. 2012;7(2):e30555
[2] Sarnoski-Brocavich S, Hilas O. Canagliflozin (Invokana), Novel Oral Agent For Type-2 Diabetes. P T. 2013 Nov;38(11):656-66

Product Citation

Bahia Abbas Moussa, Marianne Alphonse Mahrouse, et al. "Njira zosiyanasiyana zothanirana ndi mawonedwe ophatikizika: Kugwiritsa ntchito kuti mudziwe za mankhwala a hypoglycemic omwe adapangidwa mumtundu wawo wophatikizika wamankhwala." Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Ipezeka pa intaneti 20 June 2018.

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