Mbiri

Agomelatine ndi agonist wa melatonin zolandilira komanso wotsutsa serotonin 5-HT2C cholandilira chokhala ndi Ki values ​​ya 0.062nM ndi 0.268nM ndi IC50 mtengo wa 0.27μM, motsatana kwa MT1, MT2 ndi 5-HT2C [1].

Agomelatine ndi antidepressant wapadera ndipo amapangidwira kuchiza matenda ovutika maganizo (MDD). Agomelatine imasankha motsutsana ndi 5-HT2C. Imawonetsa kugwirizana kochepa kwa anthu opangidwa ndi 5-HT2A ndi 5-HT1A. Kwa ma receptor a melatonin, agomelatine amawonetsa kufanana kofananira ndi anthu opangidwa ndi MT1 ndi MT2 okhala ndi ma Ki a 0.09nM ndi 0.263nM, motsatana. M'maphunziro a mu vivo, agomelatine imayambitsa kuchuluka kwa dopamine ndi noradrenaline poletsa kulowetsedwa kwa 5-HT2C. Kuphatikiza apo, kasamalidwe ka agomelatine kumatsutsana ndi kuchepa kwapang'onopang'ono kwa kumwa sucrose mumtundu wa makoswe wa kukhumudwa. Kupatula apo, agomelatine imakhala ndi mphamvu yochepetsera nkhawa mumtundu wa rodent wa nkhawa [1].

Zolozera:
[1] Zupancic M, Guilleminault C. Agomelatine. Mankhwala a CNS, 2006, 20 (12): 981-992.

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